of Texas Medical Branch researchers may have found a new medication
that will work with an infected individual’s own body to suppress
the virus even more than current HIV treatments have not been able to
the new drug could be used in conjunction with other HIV
antiretroviral therapy drugs, it’s also possible that the new drug
could result in HIV remission without the need of ART medications for
the rest of a person’s life.
challenge that comes with fighting HIV is that it integrates itself
into a person’s genetic code and leads to a continuous dormant
infection., which makes it that much more difficult to treat the
disease. This is why some of the current ART medicines are unable to
cure the virus, and when a person quits using it, the virus begins
problem with ART medications is that they can become drug resistance,
and any HIV treatment goal includes the ability to keep the virus in
assistant professor Haito Hu said the researchers were the first to
demonstrate that BRD4 protein and machinery is able to control the
suppressed dormant HIV. He said it helps researchers to understand
HIV’s biology, and they can now work toward an approach that can
silence HIV and potentially lead to a cure of the disease.
found BRD4 has a huge role in the regulating of making new HIV gene
copies. The team came up with a design that evaluated and
manufactured small molecules to the BRD4 to suppress HIV and revealed
the ZL0580 compound. The lead molecule tested HIV infection models,
and they learned that it dramatically delayed the dormant HIV
reactivation after ART was stopped.
UTMB professor of the Pharmacology and Toxicology department Jia Zhou said researchers will continue optimizing the chemical structure and effectiveness as well as carry out safety testing in both animal and cellular studies. Zhou said the time is coming where clinical trials can begin, and HIV-infected people can get the help they need.