who have non-alcoholic fatty liver disease, HIV and lipodystrophy
could have an increased risk for suffering from type 2 diabetes.
infected individuals are at risk for developing NAFLD, and prior
studies have shown that NAFLD is more common in HIV people than those
who don’t have HIV. There is also an increased chance for
lipodystrophy for people who have HIV and do a combination
antiretroviral therapy (zidovudine and stavudine).
which is antiretroviral-drug induced, is noted by lipoatrophy, which
also has insulin resistance features such as disturbed glucose
metabolism, and increases liver fat. People who have lipodystrophy
and HIV have an increased chance for T2DM, but there have been no
longitudinal studies. The study looked at the natural progression of
NAFLD and T2DM in HIV-positive individuals who did and did not have
lipodystrophy over the course of 15+ years.
HIV positive people were involved with the study, and another 28
healthy individuals were included. Baseline measurements for clinical
characteristics and protein magnetic resonance spectroscopy were
taken at the start, and again, when the study was over. Researchers
measured for liver stiffness to measure the liver fibrosis using both
magnetic resonance elastography and transient elastography.
the study’s 16 years, the results showed T2DM progression was more
common in HIV positive individuals than NAFLD progression. They also
gained more bodyweight, had more insulin resistance features
(insulin, fasting glucose, etc.) and were at increased risk for
look at the people without lipodystrophy found that LFAT was more at
the baseline than those without it. But, it stayed stable in all the
groups at the follow-up. It also found that liver stiffness with
transient elastography was about the same at the follow-up, and there
was liver stiffness in both groups. In three lipodystrophy patients,
there was advanced fibrosis but none with the non-lipodystrophy.
authors determined, using the current determinations of liver
stiffness, that advanced fibrosis is an extremely rare complication
when likened type HIV positive individuals with type 2 diabetes.